Individuals With Multijoint Osteoarthritis Demonstrate Larger Longitudinal Declines in Frailty: Data From the Canadian Longitudinal Study on Aging
Main finding · Frailty progression over six years by multijoint OAResult — go to the resultΒ (association with frailty progression) 0.105 95% CI 0.027–0.170Authors' conclusion
Individuals with osteoarthritis affecting two or three joints experienced a 40% to 47% faster rate of frailty progression compared with those without osteoarthritis despite starting at a higher baseline frailty
Study context
- Population
- Participants of the Canadian Longitudinal Study on Aging; OA = self-reported physician diagnosis of knee, hip or hand
- Participants
- 13,757 participants
- Exposure
- One, two or three OA-affected joints vs no OA
- No osteoarthritisn = 10,193reference
- One-jointn = 2,535
- Two-jointn = 806
- Three-jointn = 223
- Outcome
- Frailty progression (frailty index) by number of OA-affected joints (time × multijoint OA interaction)
- Follow-up
- Six years
Methodological detailslongitudinal, linear mixed-effects models
- Longitudinal
- Linear mixed-effects models
Main finding
As reported in the abstract
Frailty progression over six years by multijoint OA
Β (association with frailty progression)
0.105
95% CI 0.027–0.170
By group
No osteoarthritis
- Frailty slope β
- 0.237
- 95% CI
- 0.225-0.247
One-joint
- Frailty slope β
- 0.293
- 95% CI
- 0.262-0.310
Two-joint
- Frailty slope β
- 0.348
- 95% CI
- 0.327-0.368
Three-joint
- Frailty slope β
- 0.330
- 95% CI
- 0.291-0.371
Frailty slope β
No osteoarthritis0.237
One-joint0.293
Two-joint0.348
Three-joint0.330
95% CI
No osteoarthritis0.225-0.247
One-joint0.262-0.310
Two-joint0.327-0.368
Three-joint0.291-0.371
Observational data: associations, not effects.
Further findings
| Outcome | β (95% CI) |
|---|---|
| Frailty progression, multijoint (≥2 joints) vs single-joint OA · six years | 0.070 (0.029–0.109) |
Baseline frailty
- Lowest without OA, followed stepwise by one-, two- and three-joint groups
- P < 0.001
Original publication
Individuals With Multijoint Osteoarthritis Demonstrate Larger Longitudinal Declines in Frailty: Data From the Canadian Longitudinal Study on Aging. Arthritis Care Res (Hoboken). Published 17 August 2026. doi:10.
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