Immediate reductions in compressive and shear forces in the knee from gait retraining are associated with slowed cartilage degeneration after 1 year in medial knee osteoarthritis: A retrospective observational cohort study
Authors' conclusion
Baseline and immediate changes in knee loading metrics during the initial adoption of a gait modification are associated with improvements in MRI-estimated measures of cartilage microstructure after one year of gait retraining.
Study context
- Population
- Participants with medial knee OA who walked with a personalized gait modification (modified foot progression angle) reducing peak knee adduction moment
- Participants
- 25 participants
- Outcome
- Relationship between immediate knee loading changes (musculoskeletal modeling) and change in T1ρ and T2 relaxation times (magnetic resonance imaging (MRI)) in the medial weight-bearing compartment
- Follow-up
- 1 year
Methodological detailsobservational, one-year, canonical correlation analysis
- Observational
- One-year
- Canonical correlation analysis
Main finding
As reported in the abstract
Canonical correlation analysis (CCA): cartilage microstructure changes vs knee loading metrics, r
0.84
95% CI 0.66–0.93p<0.0001
Reduction in late-stance peak anteroposterior shear force (medial compartment) vs reduction in T2 relaxation time, medial weight-bearing femoral cartilage, r
0.43
95% CI 0.05–0.71p=0.03
Reduction in late-stance vertical force (medial compartment) vs reduction in T2 relaxation time, medial weight-bearing femoral cartilage, r
0.42
95% CI 0.03–0.70p=0.04
Observational data: associations, not effects.
Original publication
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