Association of Muscle Quantity and Quality With Knee Extension Strength in Knee Osteoarthritis: The Nagahama Study
Authors' conclusion
Lower-limb muscle quality was associated with knee extension strength, and the association was stronger in patients with knee OA.
Study context
- Population
- Participants of the Nagahama Prospective Cohort (63.6% women; mean ± SD age 68.0 ± 5.3 years)63.6% women
- Participants
- 1,525 participants
- Exposure
- Control vs Early Osteoarthritis (OA) vs Advanced OA
- Outcome
- Association of lower-limb muscle quantity (muscle mass) and quality (ECW-to-ICW ratio, by bioelectric impedance analysis (BIA)) with knee extension strength
Methodological detailsmultiple linear regression, subgroup analyses by OA severity
- Multiple linear regression
- Subgroup analyses by OA severity
Main finding
As reported in the abstract
Association with knee extension strength (all participants)
- Muscle mass significantly associated with knee extension strength
- P < 0.001
- Extracellular water (ECW)-to-ICW ratio significantly associated with knee extension strength
- P = 0.009
Observational data: associations, not effects.
Further findings
Association with knee extension strength, Control (subgroup)
- Muscle mass significantly associated
- P < 0.001
- No association of ECW-to-ICW ratio
- P = 0.731
Association with knee extension strength, Early OA (subgroup)
- Muscle mass significantly associated
- P < 0.001
- ECW-to-ICW ratio significantly associated
- P = 0.034
Association with knee extension strength, Advanced OA (subgroup)
- Muscle mass significantly associated
- P < 0.001
- ECW-to-ICW ratio significantly associated
- P = 0.015
Original publication
Association of Muscle Quantity and Quality With Knee Extension Strength in Knee Osteoarthritis: The Nagahama Study. Arthritis Care Res (Hoboken). Published 4 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →