Objective sleep characteristics and incident osteoarthritis risk: A prospective analysis of the UK biobank cohort
Authors' conclusion
Delayed sleep timing and weaker circadian rhythm strength were associated with higher incident OA risk, with particularly higher risk observed when delayed sleep timing was accompanied by weaker circadian rhythmicity, extending previous evidence on sleep duration and quality by highlighting sleep timing and circadian rhythmicity.
Study context
- Population
- UK Biobank participants free of osteoarthritis (OA) at baseline with accelerometer data
- Participants
- 61,904 participants
- Exposure
- Objective sleep characteristics and incident OA
- Outcome
- Incident OA
Methodological detailsaccelerometer-derived sleep metrics, Cox models, restricted cubic splines, interaction analyses
- Accelerometer-derived sleep metrics
- Cox models
- Restricted cubic splines
- Interaction analyses
Main finding
As reported in the abstract
Longer average sleep duration, HR
0.93
95% CI 0.91–0.95
Higher sleep efficiency, HR
0.95
95% CI 0.92–0.97
Stronger relative amplitude, HR
0.93
95% CI 0.90–0.95
Delayed sleep midpoint, HR
1.08
95% CI 1.05–1.11
Observational data: associations, not effects.
Further findings
Non-linearity (restricted cubic splines (RCS))
- Significant non-linear associations for these four metrics except sleep efficiency
Interaction: circadian rhythmicity and sleep midpoint
- Stronger circadian rhythmicity may attenuate the OA risk associated with delayed sleep midpoint
OA by joint site
- Associations broadly consistent for weight-bearing joint (hip and knee) OA, but not non-weight-bearing joint (hand) OA
Original publication
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