Absence of Improvement With Exercise in Some Patients With Knee Osteoarthritis: A Qualitative Study of Responders and Nonresponders
Authors' conclusion
Responders and nonresponders shared some similar perceptions of exercise. However, along with perceived limitations in trial outcome measurements, nonresponders encountered challenges with excess weight, comorbidities, stressors, and life events that led to suboptimal adherence and collectively were perceived to contribute to nonresponse.
Study context
- Population
- Participants with knee OA in a physical therapist-supported exercise and physical activity programof 40 invited
- Participants
- 26 participants
- Comparison
- Responders vs nonresponders to an exercise and physical activity intervention
- Respondersn = 12
- Nonrespondersn = 14
- Primary endpoint
- Patients' perceptions of why they did, or did not, respond to the program
Methodological detailssemistructured individual interviews, inductive thematic analysis using grounded theory principles, deductive comparison across subgroups, triangulated with quantitative data
- Semistructured individual interviews
- Inductive thematic analysis using grounded theory principles
- Deductive comparison across subgroups
- Triangulated with quantitative data
Primary result
As reported in the abstract
Perceptions of response to exercise
- Common (sub)themes: intervention components facilitating engagement, personal attitudes and expectations, beliefs about OA and exercise role, importance of adherence, perceived strength gains
- Responders felt empowered to self-manage
- Nonresponders accepted responsibility for lack of improvement, acknowledging suboptimal adherence (confirmed by quantitative adherence data)
- Nonresponders believed excess body weight (supported by quantitative data) contributed, encountered exercise barriers (comorbidities, stressors, life events), and perceived trial measurement tools did not capture their response
Original publication
Absence of Improvement With Exercise in Some Patients With Knee Osteoarthritis: A Qualitative Study of Responders and Nonresponders. Arthritis Care Res (Hoboken). Published 18 February 2023. doi:10.
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