Metabolomic Signatures of Dietary Patterns and Incident Radiographic Knee Osteoarthritis: A Case-Cohort Study From the Osteoarthritis Initiative
Authors' conclusion
Metabolomic signatures of healthy dietary patterns may be linked to a lower risk of radiographic knee OA, with BMI potentially playing an intermediary role.
Study context
- Population
- Participants from the Osteoarthritis Initiative; 6-year follow-up237 cases · 366 noncases
- Participants
- 603 participants
- Exposure
- Highest vs lowest quartile of metabolomic signature scores of dietary patterns
- Outcome
- Incident radiographic knee osteoarthritis (OA) (Kellgren-Lawrence grade ≥ 2)
- Follow-up
- 6-year follow-up
Methodological detailsweighted logistic regression, principal component analysis
- Weighted logistic regression
- Principal component analysis
Main finding
As reported in the abstract
Incident radiographic knee OA, 2 signatures associated with healthy food groups
Highest quartile vs Lowest quartileOdds ratio (95% CI)
First healthy-food signature; adjusted for age, sex, other covariates
0.69(0.44–1.08)
Second healthy-food signature; adjusted for age, sex, other covariates
0.61(0.40–0.92)
Observational data: associations, not effects.
Further findings
Proportion of association mediated through BMI
- First healthy-food signature
- 43.7%
- Second healthy-food signature
- 81.4%
Original publication
Metabolomic Signatures of Dietary Patterns and Incident Radiographic Knee Osteoarthritis: A Case-Cohort Study From the Osteoarthritis Initiative. J Rheumatol. Published 15 December 2025. doi:10.
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