Test–retest precision and longitudinal cartilage thickness loss in the IMI-APPROACH cohort
Authors' conclusion
IMI-APPROACH successfully enrolled participants with substantial cartilage thickness loss, although the machine-learning-estimated s-score was not observed to be predictive of cartilage thickness loss.
Study context
- Population
- IMI-APPROACH participants (78% females, age 66.4 ± 7.1 years, body mass index (BMI) 28.1 ± 5.3 kg/m², 55% with radiographic knee osteoarthritis (OA)), 1.5T or 3T MRI270 with follow-up MRI
- Participants
- 297 participants
- Exposure
- Highest vs lowest s-score quartile for odds of femorotibial cartilage thickness progression
- Outcome
- Test-retest precision and longitudinal change in femorotibial cartilage thickness; % knees with progression; predictive value of s-score
- Follow-up
- 24 months
Methodological detailsexploratory, 5-center, 2-year prospective follow-up
- Exploratory
- 5-center
- 2-year prospective follow-up
Main finding
As reported in the abstract
Cartilage thickness loss, entire femorotibial joint
Test-retest precision, entire femorotibial joint (μm)
69
Mean cartilage thickness change
−174
μm; 95% CI −207, −141
Knees with progression
32.7%
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Test–retest precision and longitudinal cartilage thickness loss in the IMI-APPROACH cohort. Osteoarthritis Cartilage. Published 3 November 2022. doi:10.
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