Whole grain consumption and risk of radiographic knee osteoarthritis: a prospective study from the Osteoarthritis Initiative
Main finding · Incident radiographic knee OA by total whole grain consumptionResult — go to the resultHazard ratio 0.66 95% CI 0.52–0.84Authors' conclusion
Our findings revealed a significant inverse association of whole grain consumption with knee OA risk.
Study context
- Population
- Osteoarthritis Initiative participants aged 45–79 years, free from radiographic knee OA (Kellgren-Lawrence grade <2) in at least one knee at baseline518 developed incident knee OA
- Participants
- 2,846 participants
- Exposure
- Highest vs lowest quartile of whole grain consumption
- Outcome
- Incident radiographic knee OA (Kellgren-Lawrence grade ≥2)
- Follow-up
- 96 months
Methodological detailsCox proportional hazards models, adjusted for demographic, socio-economic, clinical and other dietary factors
- Cox proportional hazards models
- Adjusted for demographic, socio-economic, clinical and other dietary factors
Main finding
As reported in the abstract
Incident radiographic knee OA by total whole grain consumption
Hazard ratio
0.66
95% CI 0.52–0.84
P < 0.01 for trend
Quartile 4vs Quartile 1
HR 0.66 (95% CI 0.52–0.84); P for trend < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incident knee OA by dark bread consumption · 96 months | 0.68 (0.53–0.87) | P for trend < 0.01 | |
| Incident knee OA by cereal fibre intake · 96 months | 0.61 (0.46–0.81) | P for trend < 0.01 | |
| 0.512Hazard ratio (log scale) |
Original publication
Whole grain consumption and risk of radiographic knee osteoarthritis: a prospective study from the Osteoarthritis Initiative. Rheumatology (Oxford). Published 21 September 2022. doi:10.
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