Fatty Acid Intake and Polyunsaturated Fatty Acid Biomarkers and Risk of Total Knee or Hip Arthroplasty Among Older Women in the Women's Health Initiative
Authors' conclusion
Higher baseline intakes of arachidonic acid and EPA and DHA were associated with a modestly higher risk of THA. No association was found between fatty acids and patients who had TKAs.
Study context
- Population
- Older women in the Women's Health Initiativeerythrocyte subcohort 3,428
- Participants
- 34,990 women
- Exposure
- Highest vs lowest quartile of fatty acid intake and erythrocyte polyunsaturated fatty acids (PUFAs)
- Outcome
- Risk of THA and TKA (surrogate of severe OA), identified via linked Medicare data
Methodological detailsCox proportional hazards models, linked Medicare data
- Cox proportional hazards models
- Linked Medicare data
Main finding
As reported in the abstract
THA risk by dietary fatty acid intake
Q4 vs Q1Estimate (95% CI)P value
Arachidonic acid intake
multivariable HR 1.16(1.01–1.34)
P = 0.03EPA and DHA intake
HR 1.20(1.05–1.39)
P = 0.003Observational data: associations, not effects.
Further findings
Total hip arthroplasty (THA) risk by erythrocyte eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (BMI-adjusted models)
- Linear trend for higher THA risk with higher erythrocyte EPA and DHA
- P = 0.04
- No significant difference in THA by quartiles of erythrocyte EPA and DHA
- P = 0.10
Total knee arthroplasty (TKA) risk by erythrocyte PUFAs
- Erythrocyte PUFAs not significantly associated with risk of TKA
Original publication
Fatty Acid Intake and Polyunsaturated Fatty Acid Biomarkers and Risk of Total Knee or Hip Arthroplasty Among Older Women in the Women's Health Initiative. Arthritis Care Res (Hoboken). Published 1 April 2024. doi:10.
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