Frequent use of prescription non-steroidal anti-inflammatory drugs (NSAIDs) among people with knee or hip osteoarthritis despite contraindications to or precautions with NSAIDs
Main finding · Regular oral NSAID useResult — go to the resultAbsolute adjusted difference −0.06 95% CI −0.08 to −0.05Authors' conclusion
People with OA and contraindications/precautions to NSAIDs have a higher risk of opioid use, slightly lower risk of PT use, and continue to be prescribed NSAIDs.
Study context
- Population
- Adults aged ≥35 in Skåne region (Sweden) with incident knee or hip osteoarthritis (OA) diagnosis 2014–2018newly diagnosed OA
- Participants
- 35,173 adults
- Exposure
- People with newly diagnosed knee or hip OA with vs without contraindications or precautions to oral NSAIDs
- Contraindicationsn = 3,257
- Precautionsn = 8,351
- Outcome
- Regular oral NSAID use, regular opioid use and PT
- Follow-up
- First year after diagnosis
Methodological detailsregister-based, confounder-adjusted logistic regression with standardization
- Register-based
- Confounder-adjusted logistic regression with standardization
Main finding
Regular oral NSAID use
Absolute adjusted difference
−0.06
95% CI −0.08 to −0.05
By group
Contraindicationsvs Without
absolute adjusted difference −0.06 (95% CI −0.08 to −0.05)
As reported in the abstract
- Overall oral NSAID use
- 27%
Observational data: associations, not effects.
Further findings
| Outcome | Contraindications | Without | Adjusted difference (CI) | |
|---|---|---|---|---|
| PT use · first year after diagnosisContraindicationsvs Without | 53% | 59% | −0.03 (−0.05 to −0.01) | |
| Prescribed dispensed opioids · first year after diagnosisContraindicationsvs Without | 14% | 8% | 0.02 (0.01–0.03) | |
| −0.06−0.04−0.0200.020.04Difference (linear scale) |
- Physiotherapy (PT) use — Overall PT attendance
- 57%
- Prescribed dispensed opioids — Overall opioid use
- 10%
Original publication
Frequent use of prescription NSAIDs among people with knee or hip osteoarthritis despite contraindications to or precautions with NSAIDs. Osteoarthritis Cartilage. Published 26 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →