Epigenomic differences between osteoarthritis grades in primary cartilage
Authors' conclusion
Together, we provide the largest genome-wide methylation profiles of primary cartilage to date with enhanced and sex-specific insights into epigenetic processes underlying osteoarthritis progression.
Study context
- Population
- OA patients undergoing knee replacement surgery; primary chondrocytes96 women and 74 men
- Participants
- 170 patients
- Comparison
- Degraded vs macroscopically intact OA cartilage
- Outcome
- Genome-wide methylation differences associated with cartilage degeneration
Methodological detailsmatched low-grade and high-grade cartilage samples from the same patients, sex-stratified analysis
- Matched low-grade and high-grade cartilage samples from the same patients
- Sex-stratified analysis
Main finding
As reported in the abstract
Genome-wide methylation, high-grade vs low-grade cartilage
- Widespread epigenetic differences with enrichments of nervous system and apoptosis-related processes
- Substantial similarities between sexes, but also sex-specific markers and pathways
Original publication
Epigenomic differences between osteoarthritis grades in primary cartilage. Osteoarthritis Cartilage. Published 23 July 2024. doi:10.
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