People with short symptom duration of knee osteoarthritis benefit more from exercise therapy than people with longer symptom duration: An individual participant data meta-analysis from the osteoarthritis (OA) trial bank
Authors' conclusion
This IPD meta-analysis demonstrated that people with a relatively short symptom duration benefit more from therapeutic exercise than those with a longer symptom duration.
Study context
- Population
- People with knee OA in randomised controlled trials (RCTs) stored within the OA Trial Bank
- Participants
- 1,767 people10 RCTs
- Comparison
- Exercise therapy vs non-exercise control interventions, by symptom duration (≤1 vs >1 year; ≤2 vs >2 years)
- Outcome
- Interaction of treatment x symptom duration (dichotomised) on self-reported pain or physical function (standardised 0-100 scale)
Methodological detailsone-stage multilevel regression model, OA Trial Bank
- One-stage multilevel regression model
- OA Trial Bank
Pooled result
As reported in the abstract
MD (95% CI)
≤1 yearvs >1 yearInteraction, short-term (∼3 months) pain
−3.57(−6.76 to −0.38)
≤2 yearsvs >2 yearsInteraction, short-term (∼3 months) pain
−4.12(−6.58 to −1.66)
≤1 yearvs >1 yearInteraction, long-term (∼12 months) pain
−8.33(−12.51 to −4.15)
≤2 yearsvs >2 yearsInteraction, long-term (∼12 months) pain
−8.00(−11.21 to −4.80)
≤1 yearvs >1 yearInteraction, long-term (∼12 months) function
−5.46(−9.22 to −1.70)
≤2 yearsvs >2 yearsInteraction, long-term (∼12 months) function
−4.56(−7.33 to-1.80)
Original publication
People with short symptom duration of knee osteoarthritis benefit more from exercise therapy than people with longer symptom duration: An individual participant data meta-analysis from the OA trial bank. Osteoarthritis Cartilage. Published 18 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →