The impact of an illness perception conversation on open-label placebo response in knee osteoarthritis: A randomised controlled trial
Primary result · Change in VAS knee pain from baselineResult — go to the resultAdjusted between-group difference −0.7 95% CI −8.3 to 6.9Authors' conclusion
A conversation concerning knee pain-related IP did not augment the pain-relieving effect of an open-label placebo injection when compared to a similar control conversation concerning motivations for participating in research.
Study context
- Population
- Patients with knee OArandomised
- Participants
- 103 patients
- Comparison
- Illness perception conversation vs research participation conversation, both followed by open-label intraarticular saline injection
- Illness perception conversation (IPC)n = 52
- Research participation conversation (RPC)n = 51reference
- Primary endpoint
- Change in knee pain from baseline on a 100 mm visual analogue scale (VAS)
- Follow-up
- 2 weeks
Methodological detailssingle-blind
- Single-blind
Primary result
Change in VAS knee pain from baseline
Adjusted between-group difference
−0.7
95% CI −8.3 to 6.9
P = 0.85
Change by group
IPC
−13.7
SE 3.2
RPC
−13.0
SE 3.1
IPCvs RPC
adjusted between-group difference −0.7 (95% CI −8.3 to 6.9); P = 0.85
As reported in the abstract
Secondary outcomes
- No group differences in KOOS activities of daily living (ADL) and KOOS Quality of life (QoL)
Original publication
The impact of an illness perception conversation on open-label placebo response in knee osteoarthritis: A randomised controlled trial. Osteoarthritis Cartilage. Published 17 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →