The association between radiographic progression, functional impairment, markers of dyslipidaemia and inflammation in patients with hand osteoarthritis: a five-year longitudinal study
Authors' conclusion
Our longitudinal study revealed a significant association between systemic/local inflammation, dyslipidaemia, functional impairment and structural progression in HOA.
Study context
- Population
- Czech patients with hand OA
- Participants
- 129 patients
- Exposure
- Erosive vs non-erosive hand OA
- Erosiven = 72
- Non-erosiven = 57reference
- Outcome
- Associations between radiographic damage (Kallman score), serum biomarkers and clinical assessments
- Follow-up
- five-year follow-up
Methodological detailsfive-year follow-up, Kallman scoring by two independent readers, generalised additive modelling (GAM)
- Five-year follow-up
- Kallman scoring by two independent readers
- Generalised additive modelling (GAM)
Main finding
As reported in the abstract
Associations of radiographic progression (Kallman score)
- Kallman score consistently higher in erosive than non-erosive subtype at all time points; positive correlation with age in both groups
- Significant positive association between radiographic progression and ESR in both hand osteoarthritis (HOA) subtypes
- Positive associations with number of swollen joints and HAQ scores in all HOA patients, particularly non-erosive
- Markers of dyslipidaemia (e.g. LDL-c, atherogenic index) negatively associated with radiographic progression
- No biomarker reliably differentiated erosive from non-erosive subtypes
Observational data: associations, not effects.
Original publication
The association between radiographic progression, functional impairment, markers of dyslipidaemia and inflammation in patients with hand osteoarthritis: a five-year longitudinal study. Clin Exp Rheumatol. Published 25 July 2024. doi:10.
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