Functional alterations of peripheral blood-derived mesenchymal stem cells in erosive hand osteoarthritis: modulation by resveratrol
Authors' conclusion
PB-MSCs from EHOA patients exhibit functional alterations consistent with reduced regenerative potential. RSV preconditioning partially improved MSC viability and chondrogenic properties.
Study context
- Population
- Patients with erosive hand OA and age- and sex-matched healthy donors
- Comparison
- PB-MSCs from erosive hand osteoarthritis (EHOA) vs age- and sex-matched healthy donors; effects of resveratrol preconditioning
Methodological detailsin vitro, age- and sex-matched healthy donors
- In vitro
- Age- and sex-matched healthy donors
Main finding
As reported in the abstract
- EHOA MSC-derived chondrocytes: increased apoptosis, reduced chondrogenic potential markers, hypertrophic features and decreased extracellular matrix vs healthy donors
- Alterations in autophagy-related markers
- Resveratrol (RSV) pretreatment significantly improved cell survival, enhanced chondrogenic marker expression and increased extracellular matrix in vitro
- Serum β-catenin significantly higher in EHOA, correlated with clinical and imaging indicators of disease severity
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Functional alterations of peripheral blood-derived mesenchymal stem cells in erosive hand osteoarthritis: modulation by resveratrol. Clin Exp Rheumatol. Published 18 March 2026. doi:10.
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