Erosive hand osteoarthritis is associated with increased risk of incident osteoporotic fractures in post-menopausal women (QUALYOR cohort)
Main finding · First OP fractureResult — go to the resultHazard ratio 1.9 95% CI 1.09–3.3Authors' conclusion
ErHOA is a strong independent predictor of osteoporotic fracture in postmenopausal women
Study context
- Population
- Postmenopausal women ≥50 years (QUALYOR study), followed for 14 years; HOA assessed at the 6-year visit (baseline) by radiographs and AUSCANmean follow-up 4.6 ± 0.9 years
- Participants
- 1,180 women
- Exposure
- Erosive hand OA vs no hand OA
- Erosive hand osteoarthritis (ErHOA)n = 141
- Symptomatic HOA (SHOA)n = 340
- No HOAn = 364reference
- Outcome
- Incident OP fractures, medically confirmed
Methodological detailsCox models adjusted for key fracture risk factors, Poisson regression, linear mixed-effects models, exploratory path analysis
- Cox models adjusted for key fracture risk factors
- Poisson regression
- Linear mixed-effects models
- Exploratory path analysis
Main finding
First OP fracture
Hazard ratio
1.9
95% CI 1.09–3.3
By group
ErHOAvs No HOA
HR 1.9 (95% CI 1.09–3.3)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Incident osteoporotic (OP) fractures overall
- Women sustaining incident OP fractures
- 131 (11.1%)
- Incident OP fractures
- 166
- Mean time to event (years)
- 2.2 ± 1.4
Exploratory path analysis
- Association persisted after accounting for bone loss over time
- Exploratory
Original publication
Erosive hand osteoarthritis is associated with increased risk of incident osteoporotic fractures in post-menopausal women (QUALYOR cohort). Osteoarthritis Cartilage. Published 13 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →