Pre-teriparatide anti-osteoporosis medication therapy and fracture-related hospitalization in patients at very high fracture risk
Main finding · Fracture-related hospitalizationResult — go to the resultHazard ratio 0.92 95% CI 0.83–1.02Authors' conclusion
Prior AOM therapy was not associated with an increased fracture-related hospitalization risk after starting teriparatide in patients at very high fracture risk. However, among those who used AOM before teriparatide initiation, long-term denosumab use (≥ 3 years) was associated with an increased risk of spine fracture-related hospitalization.
Study context
- Population
- Patients at very high fracture risk initiating teriparatide, Taiwan
- Participants
- 14,770 patients
- Exposure
- Prior anti-osteoporosis medication (AOM) use vs no prior AOM use before teriparatide initiation
- AOMn = 9,127
- Non-AOMn = 5,643reference
- Outcome
- Hospitalization for major osteoporotic fractures
- Follow-up
- Within 3 years
Methodological detailsnationwide, Taiwan National Health Insurance Research Database (2013-2019)
- Nationwide
- Taiwan National Health Insurance Research Database (2013-2019)
Main finding
Fracture-related hospitalization
Hazard ratio
0.92
95% CI 0.83–1.02
P = 0.102
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | P value | |
|---|---|---|---|
| Spinal fracture-related hospitalization | 0.85 (0.73–0.98) | P = 0.026 | |
| 0.512Hazard ratio (log scale) |
Fracture-related hospitalization, prior bisphosphonate
| HR (95% CI) | ||
|---|---|---|
| Bisphosphonate | 0.85 (0.75–0.96) | |
| 0.512Hazard ratio (log scale) |
Spinal fracture-related hospitalization, prior bisphosphonate
| HR (95% CI) | ||
|---|---|---|
| Bisphosphonate | 0.83 (0.76–0.91) | |
| 0.512Hazard ratio (log scale) |
| Outcome | aHR | P value |
|---|---|---|
| Spine fracture-related hospitalization, denosumab ≥ 3 vs < 3 years | 1.86 | P = 0.011 |
| Spine fracture-related hospitalization, denosumab ≥ 3 vs < 3 years · first 6 months of transitioning | 1.98 | P = 0.031 |
Fracture and spinal fracture-related hospitalization, prior denosumab
- Decreased risk not shown in denosumab users
Original publication
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