Incidence, risk factors, prognosis of periprosthetic fractures post hip fracture: unveiling protective role of anti-osteoporotic medication
Authors' conclusion
PPFs are a serious complication following hip fracture. Post-fracture AOM initiation appears to lower the risk of PPFs and 2HFs, supporting its role as a key preventive strategy.
Study context
- Population
- Patients with hip fractures in Taiwan's National Health Insurance Research Database, January 2016 to December 2018
- Participants
- 48,082 patients
- Exposure
- Anti-osteoporotic medication (AOM) initiation after hip fracture vs no AOM; PPF vs contralateral 2HF
- PPFn = 443
- 2HFn = 2,285reference
- Outcome
- Incidence of PPFs and effect of AOM initiation after hip fracture on PPF risk
Methodological detailsnationwide claims database
- Nationwide claims database
Main finding
As reported in the abstract
PPF incidence and association of AOM use with PPF and 2HF risk
AOM use vs No AOMHazard ratio (95% CI)
Risk of PPFs
0.50(0.39–0.65)
Risk of 2HFs
0.85(0.77–0.93)
Observational data: associations, not effects.
Further findings
Mortality · 5 years
Subsequent major osteoporotic fractures (SMOFs)
PPF risk by age
- Patients aged 60-69 had a higher PPF risk
Mortality · 5 years
- Comparable between PPF and 2HF groups
Original publication
Incidence, risk factors, prognosis of periprosthetic fractures post hip fracture: unveiling protective role of anti-osteoporotic medication. Osteoporos Int. Published 8 September 2025. doi:10.
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