Metabolic and inflammatory profiles define phenotypes with clinical relevance in female knee osteoarthritis patients with joint effusion
Authors' conclusion
Our results support the existence of different KOA phenotypes with clinical relevance and differing pathways regarding their pathophysiology and disease evolution, which entails implications in patients' stratification, treatment tailoring and the search of novel and personalized therapies.
Study context
- Population
- Female knee OA patients with persistent joint effusion, consecutively recruited after a monographic OA outpatient visit
- Participants
- 168 women
- Exposure
- Four knee osteoarthritis (KOA) inflammatory phenotypes (KOIP-1 to KOIP-4) compared for clinical, radiographic and US severity and radiographic progression
- Outcome
- Phenotypes identified from 45 metabolic and inflammatory parameters
Methodological detailsunsupervised clustering (statistical and machine learning methods), consecutive recruitment, 2-year radiographic follow-up
- Unsupervised clustering (statistical and machine learning methods)
- Consecutive recruitment
- 2-year radiographic follow-up
Main finding
As reported in the abstract
KOA inflammatory phenotypes
- Four KOA inflammatory phenotypes (KOIP) identified
- 4
Observational data: associations, not effects.
Original publication
Metabolic and inflammatory profiles define phenotypes with clinical relevance in female knee osteoarthritis patients with joint effusion. Rheumatology (Oxford). Published 21 March 2023. doi:10.
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