Serum carboxymethyllysine concentration is associated with erosive hand osteoarthritis
Authors' conclusion
Serum CML concentration was lower in erosive HOA than non-erosive HOA, and cartilage CML concentration was higher in OA than non-OA cartilage.
Study context
- Population
- Patients with hand OA in the DIGItal Cohort Design (DIGICOD) cohort; OA and non-OA cartilage from PIP and metacarpo-phalangeal (MCP) joints of human cadaveric donorsDIGICOD cohort
- Participants
- 386 patients
- Exposure
- Erosive hand osteoarthritis (HOA) vs non-erosive HOA
- Outcome
- Association of serum CML and HCit concentrations with erosive HOA
- Follow-up
- Inclusion
Methodological detailscohort (DIGICOD), cadaveric cartilage analysis
- Cohort (DIGICOD)
- Cadaveric cartilage analysis
Main finding
As reported in the abstract
Serum CML concentration
P = 0.002
Observational data: associations, not effects.
Further findings
Serum HCit concentration
| Outcome | P value |
|---|---|
| CML concentration, OA vs non-OA MCPs (cadaveric)Higher in OA · reported as serum CML concentration | P = 0.01 |
- Carboxymethyllysine (CML) concentration, OA vs non-OA MCPs (cadaveric): OA MCPs 7.0 mmol/mol Lys
- CML concentration, OA vs non-OA MCPs (cadaveric): Non-OA MCPs 4.0 mmol/mol Lys
Serum homocitrulline (HCit) concentration
- Did not differ between the groups
Cartilage HCit and CML vs clinical features
- Not correlated with clinical features
Original publication
Serum carboxymethyllysine concentration is associated with erosive hand osteoarthritis. Osteoarthritis Cartilage. Published 15 March 2023. doi:10.
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