Serum tryptophan metabolites are associated with erosive hand osteoarthritis and pain: results from the DIGICOD cohort
Authors' conclusion
Tryptophan metabolites disturbance is associated with erosive HOA and pain and emphasize the role of low-grade inflammation and gut dysbiosis in HOA.
Study context
- Population
- Patients with hand OA (hand osteoarthritis (HOA)), DIGICOD cohort; baseline serum concentration of 20 tryptophan metabolites
- Participants
- 416 patients
- Exposure
- Erosive vs non-erosive hand OA
- Erosive HOAn = 141
- Non-erosive HOAn = 275reference
- Outcome
- Serum tryptophan metabolites and pathway activation associated with erosive HOA (adjusted for age, BMI and sex)
- Follow-up
- Baseline
Methodological detailscross-sectional analysis of the DIGICOD cohort, multiple logistic regressions adjusted on age, BMI and sex, Spearman's rank correlation analysis
- Cross-sectional analysis of the DIGICOD cohort
- Multiple logistic regressions adjusted on age, BMI and sex
- Spearman's rank correlation analysis
Main finding
As reported in the abstract
baseline
Erosive HOA vs Non-erosive HOAOdds ratio (95% CI)
Tryptophan
0.41(0.24–0.70)
Indole-3-aldehyde
0.67(0.51–0.90)
3-OH-anthranilic acid; reported as negatively associated
1.32(1.13–1.54)
5-OH-Tryptophan; positive association
1.41(1.13–1.77)
Pro-inflammatory kynurenine-indoleamine dioxygenase pathway, upregulated in erosive HOA
1.60(1.11–2.29)
- Serum tryptophan metabolites associated with erosive HOA
- 4
- Metabolite ratios associated with erosive HOA
- 8
- Metabolism pathway associated with erosive HOA
- 1
Observational data: associations, not effects.
Further findings
Correlation of tryptophan metabolites with HOA symptoms (Spearman)
- Metabolites correlated with HOA symptoms, mostly pain-related
- 11
- Serotonin and N-acetyl serotonin negatively correlated with number of tender joints
- Indole-3-aldehyde negatively, and 3-OH-anthranilic acid, 3-OH-kynurenine and 5-OH-Tryptophan positively correlated with number of patient-reported painful joints
- Quinolinic acid and 3-OH-kynurenine positively correlated with AUSCAN pain
Original publication
Serum tryptophan metabolites are associated with erosive hand osteoarthritis and pain: results from the DIGICOD cohort. Osteoarthritis Cartilage. Published 25 April 2023. doi:10.
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