Association of Dipeptidylpeptidase 4 ( CD26 ) With Chondrocyte Senescence and Radiographic Progression in Knee Osteoarthritis
Authors' conclusion
Our study identifies DPP-4 as a key surface marker in senescent chondrocytes and a predictor of radiographic OA progression.
Study context
- Population
- Individuals undergoing total knee replacement for osteoarthritis (OA); Prediction of Osteoarthritis Progression cohort
- Participants
- 35 TKR donors
- Comparison
- DPP-4+ vs DPP-4- chondrocytes; synovial fluid DPP-4 concentration vs radiographic OA progression
Methodological detailsex vivo cartilage and chondrocytes from total knee replacement, cohort biomarker analysis (Prediction of Osteoarthritis Progression cohort)
- Ex vivo cartilage and chondrocytes from total knee replacement
- Cohort biomarker analysis (Prediction of Osteoarthritis Progression cohort)
Main finding
As reported in the abstract
- DPP-4 expression associated with higher senescence-associated β-galactosidase activity, p16 expression, senescence-related and catabolic gene (ADAMTS5, MMP13, IL6, IL8) expression, higher senescence-associated secretory phenotype secretion, and lower anabolic gene (COL2A1, ACAN) expression in primary chondrocytes
Further findings
| Outcome | OR | P value |
|---|---|---|
| Radiographic OA progression by synovial fluid DPP-4 concentration · 3 yearsn = 57 samples | 105.32 | P = 0.015 |
Radiographic OA progression by synovial fluid DPP-4 concentration · 3 years
- Synovial fluid DPP-4 also associated with proteases (MMP-1, MMP-3), aggrecan degradation (sulfated glycosaminoglycan), activated macrophage indicators (CD14, CD163) and inflammation (IL-6) in synovial fluid
Original publication
Association of Dipeptidylpeptidase 4 ( CD26 ) With Chondrocyte Senescence and Radiographic Progression in Knee Osteoarthritis. Arthritis Rheumatol. Published 23 April 2023. doi:10.
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