Causal associations between serum amino acid levels and osteoarthritis: a Mendelian randomization study
Main finding · OA risk by genetically predicted Ala, Tyr and Ile levelsResult — go to the resultOdds ratio 0.82 95% CI 0.75–0.90Authors' conclusion
Some AAs, such as Ala, Tyr and Ile likely affects the OA risk especially at hip or knee joints.
Study context
- Population
- Summary-level genome-wide association study (GWAS) data on serum amino acid levels and osteoarthritis (OA)
- Comparison
- Genetically predicted serum amino acid levels and OA risk
- Outcome
- OA risk by genetically predicted Ala, Tyr and Ile levels
Methodological detailssummary-level GWAS data, inverse variance weighted (IVW) and Wald ratio as main analysis, MR-Egger, weighted median and Mendelian randomization (MR).RAPS sensitivity methods, multivariable MR, bidirectional MR
- Summary-level GWAS data
- IVW and Wald ratio as main analysis
- MR-Egger, weighted median and MR.RAPS sensitivity methods
- Multivariable MR
- Bidirectional MR
Main finding
As reported in the abstract
Odds ratio
0.82
95% CI 0.75–0.90
P = 1.54E-05
Ala (genetically predicted)
OR 0.82 (95% CI 0.75–0.90); P = 1.54E-05
Further findings
Early-onset all OA
- Little evidence of associations between genetically predicted amino acid (AA) levels and early-onset all OA risk
OA risk adjusted for body mass index (BMI) (multivariable MR (MVMR))
- Suggestive causal effects of Ala and tyrosine (Tyr); effects of isoleucine (Ile) substantially attenuated
Reverse direction (OA on AA levels)
- No significant associations between OA and AA levels after testing for bidirectionality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Causal associations between serum amino acid levels and osteoarthritis: a Mendelian randomization study. Osteoarthritis Cartilage. Published 22 April 2023. doi:10.
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