A higher intramuscular fat in vastus medialis is associated with functional disabilities and symptoms in early stage of knee osteoarthritis: a case–control study
Authors' conclusion
These findings suggest that higher VM intraMAT is characteristic of quadriceps muscle degeneration in early knee OA and its increase is associated with functional disabilities and symptoms.
Study context
- Population
- Participants with early knee osteoarthritis (OA) and healthy controls
- Participants
- 50 participants
- Comparison
- Early knee OA vs healthy controls
- Outcome
- Quadriceps muscle volume and intramuscular adipose tissue (intraMAT) and their association with knee dysfunction (KSS function and symptoms, WORMS)
Methodological details3.0 T magnetic resonance imaging (MRI) (T1-weighted, Dixon, 3D SPACE), univariate analysis of variance with covariates, multiple linear regression
- 3.0 T MRI (T1-weighted, Dixon, 3D SPACE)
- Univariate analysis of variance with covariates
- Multiple linear regression
Main finding
As reported in the abstract
B (Knee Society Score (KSS) function)
- 3.47
95% CI - 5.24 to - 1.71P < 0.001
Vastus medialis (VM) intramuscular adipose tissue (intraMAT)
B (KSS symptom)
- 0.63
95% CI - 1.09 to - 0.17P = 0.008
VM intraMAT
Original publication
A higher intramuscular fat in vastus medialis is associated with functional disabilities and symptoms in early stage of knee osteoarthritis: a case–control study. Arthritis Res Ther. Published 14 April 2023. doi:10.
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