Tetraspanin profiles of serum extracellular vesicles reflect functional limitations and pain perception in knee osteoarthritis
Authors' conclusion
Particular serum EV subpopulations showed clear associations with KOA pain and functional limitations
Study context
- Population
- End-stage primary knee osteoarthritis (OA) patients and controls; serum extracellular vesicles (EVs) by high-sensitivity flow cytometry and single particle interferometric reflectance imaging sensor
- Participants
- 8 vs 8
- Exposure
- End-stage knee OA patients vs controls
- Knee OA (KOA)n = 8
- Controlsn = 8reference
- Outcome
- Associations of serum EV surface markers (tetraspanins, platelet markers) with cartilage degradation, pain and functional limitations
Methodological detailscase-control, supervised and unsupervised univariate and multivariate models
- Case-control
- Supervised and unsupervised univariate and multivariate models
Main finding
As reported in the abstract
- Several EV markers were statistically significant predictors of pain, physical limitations and other aspects of well-being for KOA patients
- CD41+/CD63+/CD9+ small EVs associated with knee range of motion, physical performance and pain sensitivity
Observational data: associations, not effects.
Original publication
Tetraspanin profiles of serum extracellular vesicles reflect functional limitations and pain perception in knee osteoarthritis. Arthritis Res Ther. Published 22 January 2024. doi:10.
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