Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST)
Main finding · Radiographic hand OA, per Horvath epigenetic age accelerationResult — go to the resultOdds ratio 1.03 95% CI 0.99–1.08Authors' conclusion
Epigenetic age acceleration as measured by various well-validated epigenetic clocks based on DNA methylation was not associated with increased risk of knee, hand, or multi-joint OA independent of chronological age.
Study context
- Population
- Subset of Multicenter Osteoarthritis Study participants aged 45–69 years with no or mild radiographic knee osteoarthritis (OA)
- Participants
- 671 participants
- Exposure
- Epigenetic age acceleration and knee, hand and multi-joint OA
- Outcome
- Association of epigenetic age acceleration with knee, hand and multi-joint OA
Methodological detailslogistic regression adjusted for chronological age, sex, clinical site, smoking status and race
- Logistic regression adjusted for chronological age, sex, clinical site, smoking status and race
Main finding
As reported in the abstract
Radiographic hand OA, per Horvath epigenetic age acceleration
Odds ratio
1.03
95% CI 0.99–1.08
Horvath epigenetic age acceleration
OR 1.03 (95% CI 0.99–1.08)
Per Horvath epigenetic age acceleration, as printed
Observational data: associations, not effects.
Further findings
Prevalence of OA
- Radiographic hand OA
- 23%
- Radiographic knee OA
- 25%
- Multi-joint OA
- 8%
Mean chronological and predicted epigenetic age (SD), years
- Chronological age
- 58.4 (6.7)
- Horvath
- 64.9 (6.4)
- Hannum
- 68.6 (5.9)
- PhenoAge
- 50.5 (7.7)
- GrimAge
- 67.0 (6.2)
Original publication
Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST). Osteoarthritis Cartilage. Published 17 January 2024. doi:10.
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