Association of biochemical markers with bone marrow lesion changes on imaging—data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium
Authors' conclusion
Short-term changes in serum CTX-I, hsPRO-C2, and urinary CTX-Iβ hold the potential to be prognostic of BML progression on MRI.
Study context
- Population
- Knee Osteoarthritis (OA), FNIH OA Biomarkers Consortium within the Osteoarthritis Initiative
- Participants
- 600 participants
- Outcome
- Change in number of knee subregions affected by any BML (MRI Osteoarthritis Knee Score (MOAKS), 0-3, 15 subregions) on MRI, by 12-month change in biochemical markers
- Follow-up
- 24 months
Methodological detailsnested within the Osteoarthritis Initiative, regression models adjusted for covariates
- Nested within the Osteoarthritis Initiative
- Regression models adjusted for covariates
Main finding
As reported in the abstract
Change in number of subregions affected by any BML vs 12-month change in biochemical markers
- Increases in serum CTX-I over 12 months associated with increased odds of changes in number of subregions affected by any BML
- Increases in urinary CTX-Iβ over 12 months associated with increased odds of changes in number of subregions affected by any BML
- Increase in hsPRO-C2 associated with decreased odds of worsening in number of subregions affected by any BML
Observational data: associations, not effects.
Further findings
Tissue turnover and inflammation markers (C1M, C2M, C3M, hsPRO-C2, CRPM) and bone marrow lesions (BMLs) at baseline
- C1M and C3M associated with BMLs affected at baseline
Original publication
Association of biochemical markers with bone marrow lesion changes on imaging—data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium. Arthritis Res Ther. Published 18 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →