Specific-cytokine associations with outcomes in knee osteoarthritis subgroups: breaking down disease heterogeneity with phenotyping
Authors' conclusion
Our study adds further evidence supporting KOA as a multifaceted syndrome composed of multiple phenotypes with differing pathophysiological pathways, providing an explanation for inconsistencies between previous studies focussed on the role of cytokines in OA and the lack of translational results to date.
Study context
- Population
- Symptomatic female knee osteoarthritis (OA) patients with persistent joint effusion
- Participants
- 168 patients
- Exposure
- Associations of cytokines with knee OA severity and progression within each KOIP group vs the overall patient series
- Outcome
- Association between knee OA severity and progression and a panel of 13 cytokines in plasma and synovial fluid
Methodological detailsphenotype-specific analysis, analysis within four knee OA inflammatory phenotypes (KOIP), 13-cytokine panel in plasma and synovial fluid
- Phenotype-specific analysis
- Analysis within four knee OA inflammatory phenotypes (KOIP)
- 13-cytokine panel in plasma and synovial fluid
Main finding
As reported in the abstract
- Associations with knee OA outcomes of higher magnitude within the KOIP groups than for the overall patient series
- all p-values < 1.30e-16
Observational data: associations, not effects.
Original publication
Specific-cytokine associations with outcomes in knee osteoarthritis subgroups: breaking down disease heterogeneity with phenotyping. Arthritis Res Ther. Published 11 January 2024. doi:10.
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