Associations between markers of inflammation and altered pain perception mechanisms in people with knee osteoarthritis: a systematic review
Authors' conclusion
Signs of effusion/synovitis may be positively associated with neuropathic-like pain and pain sensitivity. There are indications of a possible positive association between serum CRP levels and pain sensitivity.
Study context
- Population
- People with knee osteoarthritis (OA); studies reporting associations between knee inflammation (effusion, synovitis, bone marrow lesions (BMLs), cytokines) and altered pain processing (quantitative sensory testing and/or neuropathic-like pain questionnaire)
- Participants
- 1,889 people9 studies
- Outcome
- Associations between knee inflammation and altered pain perception mechanisms
Methodological detailsquality assessed with NHLBI Study Quality Assessment Tool, Evidence-Based Guideline Development method for level of evidence, MEDLINE, Web of Science, EMBASE and Scopus searched up to 13 December 2022
- Quality assessed with NHLBI Study Quality Assessment Tool
- Evidence-Based Guideline Development method for level of evidence
- MEDLINE, Web of Science, EMBASE and Scopus searched up to 13 December 2022
Pooled result
As reported in the abstract
- Greater effusion/synovitis may be positively associated with lower knee pain pressure threshold (PPT) and neuropathic-like pain
- Association between BMLs and pain sensitivity could not be established
- Evidence on inflammatory cytokines and pain sensitivity or neuropathic-like pain conflicting
- Indications of positive association between higher serum C reactive protein (CRP) and lower PPT and presence of temporal summation
- Methodological quality level C to A2
Original publication
Associations between markers of inflammation and altered pain perception mechanisms in people with knee osteoarthritis: a systematic review. RMD Open. Published 24 May 2023. doi:10.
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