Postvaccination immune responses and risk of primary total hip arthroplasty—A population-based cohort study
Authors' conclusion
Our results suggest that an increased postvaccination immune response is associated with a nonsignificant trend of increased risk of THA among men and a decreased risk among women, although risk estimates were small.
Study context
- Population
- Participants of the Norwegian mandatory mass tuberculosis screening program 1948–1975 with TST results after Bacille Calmette-Guerin (BCG) vaccination, linked with the Norwegian Arthroplasty Register 1987–202010,698 received a total hip arthroplasty (THA)
- Participants
- 236,770 participants
- Exposure
- Positive or strong positive vs negative TST after BCG vaccination
- Outcome
- THA due to idiopathic OA or RA
Methodological detailsmultivariable Cox proportional hazard regression, register linkage
- Multivariable Cox proportional hazard regression
- Register linkage
Main finding
As reported in the abstract
THA due to OA, men
Each group vs negative TSTHazard ratio (95% CI)
Positive TST
1.01(0.92–1.12)
Strong positive TST
1.06(0.95–1.18)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| THA due to OA, womenPositive TSTvs Negative TST | 0.98 (0.92–1.05) | |
| THA due to OA, womenStrong positive TSTvs Negative TST | 0.90 (0.84–0.97) | |
| 0.512Hazard ratio (log scale) |
THA due to osteoarthritis (OA), women
- No significant associations in the sensitivity analysis for women
THA due to rheumatoid arthritis (RA)
- No significant associations observed for THA due to RA
Original publication
Postvaccination immune responses and risk of primary total hip arthroplasty—A population-based cohort study. Osteoarthritis Cartilage. Published 24 May 2023. doi:10.
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