Multidimensional characterization and clinical profiling of subchondral bone endotypes in hip osteoarthritis
Authors' conclusion
The consideration of subchondral bone endotypes may enable a personalized approach to the treatment of hip OA.
Study context
- Population
- Patients with hip osteoarthritis (OA) undergoing total hip arthroplasty; femoral heads obtained during surgery
- Participants
- 38 patients
- Exposure
- Cluster I vs Cluster II vs Cluster III
- Outcome
- Subchondral bone endotypes (clusters) and their clinical manifestation
Methodological detailsprincipal component analysis, hierarchical clustering
- Principal component analysis
- Hierarchical clustering
Main finding
As reported in the abstract
Subchondral bone endotypes
- Three clusters identified: I) low bone mass, low turnover; II) intermediate bone mass, high turnover; III) high bone mass, high turnover
- Cluster III stood out as an osteocyte-rich endotype
- Differences in subchondral microstructure, composition and cellular activity also reflected by variations in bone marrow adipose tissue; high turnover endotypes showed increased surrogates of lipolysis
Observational data: associations, not effects.
Original publication
Multidimensional characterization and clinical profiling of subchondral bone endotypes in hip osteoarthritis. Osteoarthritis Cartilage. Published 22 August 2025. doi:10.
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