Alterations in compositional and cellular properties of the subchondral bone are linked to cartilage degeneration in hip osteoarthritis
Main finding · Number of osteoblasts in subchondral boneResult — go to the resultAge-adjusted mean difference 10.5 mm-1 95% CI 4.7–16.4Authors' conclusion
Subchondral bone properties in OA are affected at the compositional, mechanical, and cellular levels.
Study context
- Population
- Femoral heads (central subchondral bone region) from patients with primary hip osteoarthritis (OA) and non-OA controls
- Participants
- 44 vs 30
- Comparison
- Femoral heads from primary hip OA vs non-OA controls
- OAn = 44
- Controlsn = 30reference
- Outcome
- Number of osteoblasts in subchondral bone
Methodological detailscase-control, multiscale assessment: histomorphometry, quantitative backscattered electron imaging, nanoindentation, osteocyte lacunocanalicular network characterization
- Case-control
- Multiscale assessment: histomorphometry, quantitative backscattered electron imaging, nanoindentation, osteocyte lacunocanalicular network characterization
Main finding
As reported in the abstract
Age-adjusted mean difference
10.5 mm-1
95% CI 4.7–16.4
P < 0.001
By group
OAvs Controls
age-adjusted mean difference 10.5 mm-1 (95% CI 4.7–16.4); P < 0.001
Further findings
| Outcome | OA | Controls | Age-adjusted mean difference (wt%) (95% CI) | P value | |
|---|---|---|---|---|---|
| Matrix mineralization heterogeneity (CaWidth) | 3.1 ± 0.3 wt% | 2.8 ± 0.2 wt% | 0.2 (0.1–0.4) | P = 0.011 | |
| −0.200.20.40.6Difference, wt% (linear scale) |
| Outcome | OA | Controls | Age-adjusted mean difference (GPa) (95% CI) | P value | |
|---|---|---|---|---|---|
| Tissue hardness | 0.67 ± 0.06 GPa | 0.69 ± 0.06 GPa | −0.05 (−0.09 to −0.01) | P = 0.032 | |
| −0.1−0.0500.05Difference, GPa (linear scale) |
- Number of osteoclasts
- P = 0.150
Number of osteoclasts
- Similar number of osteoclasts vs controls
Osteocyte perilacunar/canalicular remodeling
- No evidence of fewer osteocyte canaliculi in OA
- Advanced vs low-grade cartilage degeneration: more osteocyte canaliculi and larger lacunocanalicular network area
Subchondral bone properties (esp. osteoblast and osteocyte parameters) related to cartilage degeneration, multiple linear regression
- R2 adjusted
- 0.561
- p
- P < 0.001
Original publication
Alterations in compositional and cellular properties of the subchondral bone are linked to cartilage degeneration in hip osteoarthritis. Osteoarthritis Cartilage. Published 23 February 2024. doi:10.
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