Essential Fatty Acids and Osteoarthritis
Main finding · Incident symptomatic knee OAResult — go to the resultOdds ratio 1.0 95% CI 0.87–1.17Authors' conclusion
We found no association of serum levels of EPA or of other specific n-3 fatty acids or n-6 fatty acids with risk of incident knee OA or other OA outcomes.
Study context
- Population
- Multicenter Osteoarthritis Study (MOST) participants at risk of knee osteoarthritis (OA), without baseline OA; mean age 62 years (59% women)
- Comparison
- Serum levels of specific n-3 and n-6 fatty acids and incident knee OA
- Incident symptomatic knee OAn = 363
- Incident radiographic knee OAn = 295
- Outcome
- Incident radiographic OA and incident symptomatic knee OA (knee pain and radiographic OA)
- Follow-up
- 60 months
Methodological detailsMulticenter Osteoarthritis Study (MOST), baseline fasting serum samples, adjusted regression models
- Multicenter Osteoarthritis Study (MOST)
- Baseline fasting serum samples
- Adjusted regression models
Main finding
Incident symptomatic knee OA
Odds ratio
1.0
95% CI 0.87–1.17
Per SD increase in EPA
OR 1.0 (95% CI 0.87–1.17)
Per SD increase in EPA, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
Other OA outcomes (worsening MRI cartilage damage and synovitis, worsening knee pain, hand nodules)
- Failed to suggest a protective effect of specific n-3 fatty acids
Original publication
Essential Fatty Acids and Osteoarthritis. Arthritis Care Res (Hoboken). Published 14 February 2024. doi:10.
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