Effects of cetylated fatty acids on knee osteoarthritis: a systematic review and meta-analysis of real-world evidence
Pooled result · Pain levels after CFA interventionResult — go to the resultSMD −0.37 95% CI −0.60 to −0.15Authors' conclusion
Overall, CFAs may improve pain levels, knee ROM, and physical function in patients with knee OA, particularly the oral form.
Study context
- Population
- Patients with knee osteoarthritis (OA)5 randomised controlled trials (RCTs) and 2 pre-post studies
- Participants
- 357 patients
- Comparison
- Cetylated fatty acids (topical or oral) vs placebo or non-CFA treatment, or pre- vs post-treatment
- Outcome
- Pain levels after CFA intervention
Methodological detailssubgroup analyses by form of CFA
- Subgroup analyses by form of CFA
Pooled result
As reported in the abstract
SMD
−0.37
95% CI −0.60 to −0.15
P = 0.0009
CFAvs Control
SMD −0.37 (95% CI −0.60 to −0.15); P = 0.0009
Further pooled results
Subgroup analysis by form of CFA
- Significant improvements in pain, ROM and physical function only with oral CFA capsules, not CFA cream
Original publication
Effects of cetylated fatty acids on knee osteoarthritis: a systematic review and meta-analysis of real-world evidence. Clin Exp Rheumatol. Published 22 April 2025. doi:10.
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