Microstructural and cellular characterisation of the subchondral trabecular bone in human knee and hip osteoarthritis using synchrotron tomography
Authors' conclusion
SCB from hip OA and knee OA exhibits different characteristics at the tissue and cellular levels, suggesting different mechanisms of OA progression in different joints.
Study context
- Population
- Patients undergoing knee or hip arthroplasty for osteoarthritis (OA); Subchondral bone (SCB) samples
- Participants
- 8 vs 11
- Exposure
- Hip OA vs knee OA subchondral trabecular bone, relative to degree of cartilage degeneration
- Hip OAn = 8
- Knee OAn = 11reference
- Outcome
- SCB characteristics, hip OA vs knee OA
Methodological detailssynchrotron micro-CT imaging, histology
- Synchrotron micro-CT imaging
- Histology
Main finding
As reported in the abstract
Hip OA vs Knee OADifference (osteocyte lacunar volume), µm3 (95% CI)
Larger lacunae in hip OA
47.3(11.2–83.4)
Hip OA vs Knee OADifference (osteocyte lacunar sphericity) (95% CI)
Less spheric in hip OA
- 0.04(−0.06 to −0.02)
Hip OA vs Knee OADifference (vascular canal density), #/mm3 (95% CI)
SCB characteristics, hip OAvs knee OA
- 22.8(−35.4 to −10.3)
Hip OA vs Knee OAEstimate (95% CI)
SCB characteristics, hip OAvs knee OA
difference (osteocyte cell density) - 84.2 #/mm²(−102.5 to −67.4)
Less senescent in hip OA
difference (senescent osteocytes) - 2.4 #/mm²(−3.6 to −1.2)
Hip OA vs Knee OADifference (apoptotic osteocytes), % (95% CI)
More apoptotic in hip OA
24.9(17.7–32.1)
Observational data: associations, not effects.
Further findings
Association of severe cartilage degeneration with SCB changes (both knee and hip OA)
- Bone volume fraction (%) increase
- - 8.7, 95% CI (−14.1, −3.4)
- Trabecular number (#/mm) increase
- - 1.5, 95% CI (−0.8, −2.3)
- Osteocyte lacunar density (#/mm³) increase
- 4714.9; 95% CI (2079.1, 7350.6)
- Trabecular separation (mm) decrease
- - 0.07, 95% CI (0.02, 0.1)
- Found in both knee and hip OA
Original publication
Microstructural and cellular characterisation of the subchondral trabecular bone in human knee and hip osteoarthritis using synchrotron tomography. Osteoarthritis Cartilage. Published 11 May 2023. doi:10.
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