HSPA4 and SYVN1 positivity in osteoarthritis synovium as indicators of proteostasis dysfunction
Authors' conclusion
Enhanced HSPA4 and SYVN1 positivity indicates extensive activation of protein quality control processes in OA synovium.
Study context
- Population
- Knee synovium from osteoarthritis (OA) patients and two non-osteoarthritic cohorts undergoing arthroscopic (scope) or trauma surgery
- Exposure
- OA synovium vs non-osteoarthritic synovium from arthroscopic (scope) or trauma surgery
- Outcome
- Endoplasmic reticulum (ER) stress markers HSPA4 and SYVN1 in knee synovium
Methodological detailsimmunohistological staining with digital image analysis, validated questionnaires
- Immunohistological staining with digital image analysis
- Validated questionnaires
Main finding
As reported in the abstract
- HSPA4 and SYVN1 positivity highest and mutually correlated in OA
- OA SYVN1 positivity correlated with all inflammatory cells, vessels, synovitis, BMI and symptom duration
- OA HSPA4 positivity correlated with CD3, vimentin and KL grade
Observational data: associations, not effects.
Further findings
Synovial cellular composition
- Inflammatory cell infiltration and angiogenesis highest in OA synovium
- Increased small blood vessels in trauma tissues vs OA, suggesting a continuum of remodelling responses from acute injury to OA
- Adipocyte hyperplasia and hypertrophy, influenced by dyslipidaemia, highest in OA synovium, indicating metabolic stresses
Original publication
HSPA4 and SYVN1 positivity in osteoarthritis synovium as indicators of proteostasis dysfunction. Clin Exp Rheumatol. Published 21 August 2025. doi:10.
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