Cellular characterisation of advanced osteoarthritis knee synovium
Authors' conclusion
There are significant differences in the relative proportions and subsets of immune cells in OA synovium; exploratory correlative analyses suggest that these differences might be correlated with age, clinical scores, or fibroblast subsets.
Study context
- Population
- Patients with advanced knee osteoarthritis (OA) undergoing total knee replacement surgery
- Participants
- 10 patients
- Outcome
- Cellular composition of advanced OA synovium
Methodological detailsflow cytometry, multiplex immunofluorescence (Cell DIVE)
- Flow cytometry
- Multiplex immunofluorescence (Cell DIVE)
Main finding
As reported in the abstract
Cellular composition of OA synovium
Proportion of immune cells, range across patients
8-38% of all cells
Macrophages and T cells together, share of immune cells
76%
Patients with CCR6+ T cells (had higher mean Kellgren-Lawrence grade across three knee compartments)
6 of 10
Original publication
Cellular characterisation of advanced osteoarthritis knee synovium. Arthritis Res Ther. Published 23 August 2023. doi:10.
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