A scoping review of how early-stage knee osteoarthritis has been defined
Authors' conclusion
Early-stage KOA is variably defined in the published literature. Most studies included KL grades of 2 or higher within their definitions, which reflects established or later-stage OA.
Study context
- Population
- Human studies where early-stage knee osteoarthritis (OA) was included as a study population or outcomeof 6142 articles identified
- Participants
- 211 participants
- Outcome
- How early-stage knee OA has been defined in the literature
Methodological detailsliterature search of PubMed, EMBASE, Cochrane and Web of Science
- Literature search of PubMed, EMBASE, Cochrane and Web of Science
Main finding
As reported in the abstract
Elements used to define early-stage knee OA
- Kellgren-Lawrence (KL) grade
- 151 studies, 72%
- Symptoms
- 118 studies, 56%
- Demographic characteristics
- 73 studies, 35%
- Previously developed early-stage knee OA composite criteria
- 14 studies (6%)
- Definition used for study inclusion
- 194 studies
- Definition used to define study outcomes
- 11 studies
- Definition used in new criteria development or validation
- six studies
Further findings
Radiographic definitions by KL grade alone
- Studies defining early-stage knee OA by KL grade alone
- 52
- Of these, studies including KL grade 2 or higher
- 44 (85%)
Original publication
A scoping review of how early-stage knee osteoarthritis has been defined. Osteoarthritis Cartilage. Published 22 May 2023. doi:10.
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