Development of a Magnetic Resonance Imaging–Based Definition of Knee Osteoarthritis: Data From the Multicenter Osteoarthritis Study
Authors' conclusion
An MRI OA definition requiring cartilage damage and a small osteophyte with or without BMLs or synovitis had the best performance and was simplest for identifying radiographic OA and symptomatic OA.
Study context
- Population
- Multicenter Osteoarthritis Study participants with knee symptoms, with knee radiographs and magnetic resonance imaging (MRIs) (mean age 66 years, 62% female, 89% White)
- Participants
- 1,185 knees
- Comparison
- MRI definitions of knee osteoarthritis (OA) (combinations of MRI features) vs radiographic OA and symptomatic OA as validation criteria
- Outcome
- Sensitivity, specificity and AUC of each MRI definition for prevalent radiographic OA (Kellgren/Lawrence grade ≥2 in TF and/or PF joint) and symptomatic OA
Methodological detailsmulticentre
- Multicentre
Performance
As reported in the abstract
Prevalent radiographic OA
| Strategy | AUC | Sensitivity |
|---|---|---|
| Cartilage ≥2 + osteophyte ≥2 | 0.67 | 95.2% |
| Cartilage ≥2 + osteophyte ≥2 + bone marrow lesions (BMLs) or synovitis ≥1 | 0.69 | 94.5% |
AUC
Cartilage ≥2 + osteophyte ≥20.67
Cartilage ≥2 + osteophyte ≥2 + bone marrow lesions (BMLs) or synovitis ≥10.69
Sensitivity
Cartilage ≥2 + osteophyte ≥295.2%
Cartilage ≥2 + osteophyte ≥2 + bone marrow lesions (BMLs) or synovitis ≥194.5%
Further findings
- Cartilage ≥2 + osteophyte ≥2 definitions (with or without BMLs or synovitis ≥1) also had the highest sensitivities for symptomatic OA
- 524 knees had symptomatic OA
Original publication
Development of a Magnetic Resonance Imaging–Based Definition of Knee Osteoarthritis: Data From the Multicenter Osteoarthritis Study. Arthritis Rheumatol. Published 26 April 2023. doi:10.
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