Do Existing Magnetic Resonance Imaging Definitions of Knee Osteoarthritis Identify Knees That Will Develop Clinically Significant Disease Over Up To 11 Years of Follow‐Up?
Authors' conclusion
Current MRI definitions of knee OA do not adequately identify knees that will develop radiographic and symptomatic disease.
Study context
- Population
- Osteoarthritis Initiative participants without tibiofemoral radiographic knee osteoarthritis (OA) at baseline (mean age 58.8 years; 59.5% women)
- Participants
- 1,621 participants
- Exposure
- Baseline magnetic resonance imaging (MRI)-defined knee OA vs no MRI-defined knee OA
- Outcome
- Incident tibiofemoral radiographic knee OA: (1) KL ≥2, (2) KL ≥2 and JSN, or (3) KL ≥2 and frequent knee symptoms
- Follow-up
- Up to 11 years
Methodological detailsadjusted Cox proportional hazards regression
- Adjusted Cox proportional hazards regression
Main finding
As reported in the abstract
Incident KL ≥2
Odds ratio (95% CI)
Def A
2.94(2.34–3.68)
Def B
2.44(1.97–3.03)
Observational data: associations, not effects.
Further findings
Incident kellgren-Lawrence (KL) ≥2 and joint space narrowing (JSN); incident KL ≥2 and Sx · up to 11 years
- Findings were similar for the other two outcomes
Original publication
Do Existing Magnetic Resonance Imaging Definitions of Knee Osteoarthritis Identify Knees That Will Develop Clinically Significant Disease Over Up To 11 Years of Follow‐Up? Arthritis Rheumatol. Published 17 October 2024. doi:10.
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