Associations of healthy lifestyle and genetic susceptibility with risks of osteoarthritis: a prospective cohort study
Authors' conclusion
These data suggest that a healthier lifestyle is consistently associated with a lower risk of OA, regardless of genetic risks.
Study context
- Population
- UK Biobank participantsUK Biobank
- Participants
- 314,729 participants
- Exposure
- Favourable vs unfavourable lifestyle, across genetic risk groups
- Outcome
- Incident total OA (ICD-9 and ICD-10)
Methodological detailsCox regression, polygenic risk score, adjusted for age, sex, education, Townsend deprivation index, glucosamine use, analgesics use and comorbidities
- Cox regression
- Polygenic risk score
- Adjusted for age, sex, education, Townsend deprivation index, glucosamine use, analgesics use and comorbidities
Main finding
As reported in the abstract
Total OA, favourable vs unfavourable lifestyle, by genetic risk group
Favourable lifestyle vs Unfavourable lifestyleHazard ratio (95% CI)
Low genetic risk
0.64(0.58–0.70)
Intermediate genetic risk
0.59(0.56–0.63)
High genetic risk
0.58(0.53–0.64)
- More favourable lifestyle significantly reduced risk of incident total, knee and hip OA
- all P < 0.01
Observational data: associations, not effects.
Further findings
Knee OA and hip OA
- Similar results observed on knee OA and hip OA
Polygenic risk score (PRS) and OA
- PRS significantly associated with greater risks of total, knee and hip OA
Lifestyle × PRS interaction
- No significant interactions between lifestyle and PRS for total, knee or hip OA
Original publication
Associations of healthy lifestyle and genetic susceptibility with risks of osteoarthritis: a prospective cohort study. Rheumatology (Oxford). Published 20 June 2025. doi:10.
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