Longitudinal Associations Between Baseline Sarcopenia and Knee Osteoarthritis Progression and Risk of Knee Replacement
Authors' conclusion
Scre-S and Prob-S were significantly and longitudinally associated with both radiographic and symptomatic progression in KOA and subsequent KR.
Study context
- Population
- Participants of the Osteoarthritis Initiative (knee OA)
- Participants
- 4,316 participants
- Exposure
- Baseline sarcopenia vs no sarcopenia
- Outcome
- Radiographic (Kellgren-Lawrence Grade, OARSI atlas scores) and symptomatic (WOMAC) KOA progression and subsequent knee replacement
- Follow-up
- 24 and 48 months
Methodological detailslongitudinal, propensity score matching, adjusted for potential confounders
- Longitudinal
- Propensity score matching
- Adjusted for potential confounders
Main finding
As reported in the abstract
Subsequent knee replacement
Hazard ratio (95% CI)
Scre-S
3.84(3.18–4.62)
Prob-S
2.29(1.87–2.81)
Observational data: associations, not effects.
Further findings
Prevalence of sarcopenia at baseline
Original publication
Longitudinal Associations Between Baseline Sarcopenia and Knee Osteoarthritis Progression and Risk of Knee Replacement. Arthritis Rheumatol. Published 19 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →