Effect of a combination of C. longa and B. serrata extracts on hand osteoarthritis. Results of a double-blind, randomized, placebo-controlled, multicenter trial
Primary result · Pain VAS, mean decrease from baselineResult — go to the resultDifference between groups −8.5 mm 95% CI −16.4 to −0.6Authors' conclusion
CBTIL relieves pain in patients with hand osteoarthritis.
Study context
- Population
- Patients with symptomatic hand OA meeting ACR criteria, BMI ≤ 35 Kg/m²
- Participants
- 162 patients
- Comparison
- CBTIL two tablets per day vs placebo for 3 months
- CBTILn = 83
- Placebon = 79reference
- Primary endpoint
- Difference in pain change on VAS between baseline and month 3
- Follow-up
- Month 3
Methodological detailsdouble-blind, placebo-controlled, multicentre
- Double-blind
- Placebo-controlled
- Multicentre
Primary result
Pain VAS, mean decrease from baseline
Difference between groups
−8.5 mm
95% CI −16.4 to −0.6
P = 0.03
Change by group
CBTIL
−24.7
mean · 95% CI −30.7–-18.7 · mm
Placebo
−16.2
mean · 95% CI −22.5–-9.9 · mm
CBTILvs Placebo
Difference between groups −8.5 mm (95% CI −16.4 to −0.6); P = 0.03
As reported in the abstract
Secondary outcomes
| Outcome | Difference (mm) (95% CI) | |
|---|---|---|
| Patient global assessment · 3 months | −9.6 (−16.9 to −2.2) | |
| −20−10010Difference, mm (linear scale) |
| Outcome | OR (95% CI) | |
|---|---|---|
| Patients achieving acceptable symptom status (PASS) · 3 months | 1.9 (1.0–3.8) | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | Difference (units) (95% CI) | |
|---|---|---|
| SF-36 pain · 3 months | 7.1 (1.7–12.4) | |
| SF-36 health change · 3 months | 6.7 (1.2–12.2) | |
| −5051015Difference, units (linear scale) |
Other secondary outcomes
- Did not significantly differ between the two groups
Safety
Adverse events
- No significant difference between the groups
Original publication
Effect of a combination of C. longa and B. serrata extracts on hand osteoarthritis. Results of a double-blind, randomized, placebo-controlled, multicenter trial. Osteoarthritis Cartilage. Published 17 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →