MRI-based patient-specific nomogram for diagnostic risk stratification of patients with early knee OA
Authors' conclusion
A smaller volume of IPFP, T1ρ value >33 and T2 mapping >35.04 were significantly associated with OA.
Study context
- Population
- Patients with cartilage diagnosed as early-stage knee OA or normal, evaluated by MRI including T1rho and T2 mapping79 (39.7%) early OA
- Participants
- 199 patients
- Comparison
- Training vs Validation
- Trainingn = 115
- Validationn = 84
- Outcome
- Discrimination of the OA-anatomical signature-nomogram (OA-ASN) for early-stage OA (C-index)
Methodological detailstraining and validation cohorts, bootstrap validation, multivariable analysis
- Training and validation cohorts
- Bootstrap validation
- Multivariable analysis
Performance
As reported in the abstract
OA-ASN discrimination (C-index)
| Test or model | Value | Bootstrap validation concordance index (C-index) |
|---|---|---|
| Training | C-index 0.975 (95% CI 0.951–0.999) | 0.96 |
| Validation | C-index 0.904 (95% CI 0.840–0.959) |
Value
TrainingC-index 0.975 (95% CI 0.951–0.999)
ValidationC-index 0.904 (95% CI 0.840–0.959)
Bootstrap validation concordance index (C-index)
Training0.96
Validation— not stated in the abstract
Further findings
Independent predictors of early-stage OA (multivariable analysis)
- Infrapatellar fat pad (IPFP), T1 rho and T2 mapping independently associated with early-stage OA
Calibration
- Favourable consistency between nomogram prediction and actual observations in both training and validation cohorts
Clinical utility (decision curve analysis (DCA) and clinical impact curve (CIC))
- Nomogram clinically useful
Original publication
MRI-based patient-specific nomogram for diagnostic risk stratification of patients with early knee OA. Rheumatology (Oxford). Published 6 June 2025. doi:10.
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