Cartilage tissue turnover increases with high- compared to low-intensity resistance training in patients with knee osteoarthritis (OA)
Authors' conclusion
Cartilage tissue turnover and cartilage degradation appear to increase in response to a 3-month exercise-related joint loading training program and at 6-month follow-up, with no evident difference in type II collagen formation. Aggrecan remodeling increased more with high-intensity resistance training than with low-intensity exercise.
Study context
- Population
- Patients with knee OA
- Comparison
- High-intensity vs low-intensity resistance training
- Primary endpoint
- Cartilage tissue turnover biomarkers (huARGS, C2M, PRO-C2) measured by ELISA
Methodological detailsexploratory biomarker analysis, linear mixed models with baseline values as covariates
- Exploratory biomarker analysis
- Linear mixed models with baseline values as covariates
Primary result
As reported in the abstract
huARGS level · after resistance training and at follow-up
- huARGS and C2M levels increased after training and at follow-up in both groups
- No changes in PRO-C2
- High-intensity vs Low-intensity: P = 0.029
- High-intensity vs Low-intensity: P = 0.003
Original publication
Cartilage tissue turnover increases with high- compared to low-intensity resistance training in patients with knee OA. Arthritis Res Ther. Published 10 February 2023. doi:10.
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