Association of polycyclic aromatic hydrocarbons with osteoarthritis among adults: an analysis of the National Health and Nutrition Examination Survey (NHANES) 2001-2016
Authors' conclusion
Both individual and mixed exposure to PAHs were positively correlated with the risk of osteoarthritis.
Study context
- Population
- Adults aged ≥20 years with data on urinary polycyclic aromatic hydrocarbons (PAHs) and OA, NHANES 2001–2016980 (9.23%) with OA
- Participants
- 10,613 adults
- Exposure
- High vs lower levels of urinary PAHs
- Outcome
- OA
Methodological detailslogistic regression, quantile-based g computation (qgcomp), Bayesian kernel machine regression (BKMR)
- Logistic regression
- Quantile-based g computation (qgcomp)
- Bayesian kernel machine regression (BKMR)
Main finding
As reported in the abstract
Odds of OA with high levels of individual PAHs (adjusted for age, sex, BMI, drinking alcohol, hypertension)
Odds ratio (95% CI)
High 1-hydroxynaphthalene (1-NAP)
1.06(1.01–1.10)
High 3-hydroxyfluorene (3-FLU)
1.09(1.02–1.17)
High 2-hydroxyfluorene (2-FLU)
1.06(1.01–1.13)
Observational data: associations, not effects.
Further findings
OA with mixed PAHs exposure, joint weighted value (qgcomp)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Mixed PAHs exposure | 1.11 (1.02–1.22) | P = 0.017 | |
| 0.512Odds ratio (log scale) |
OA with mixed PAHs exposure (BKMR)
- Mixed exposure to PAHs positively correlated with risk of OA
Original publication
Association of polycyclic aromatic hydrocarbons with osteoarthritis among adults: an analysis of the NHANES 2001-2016. Clin Exp Rheumatol. Published 7 February 2023. doi:10.
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