Changes and Associations Between Gait Biomechanics and Knee Inflammation After Aspiration and Glucocorticoid Injection for Knee Osteoarthritis
Authors' conclusion
In patients with knee OA and synovitis, reduced inflammation and pain after aspiration and glucocorticoid injection are associated with changes in knee gait biomechanics and strength.
Study context
- Population
- Patients with symptomatic knee osteoarthritis (OA) and synovitis69 knees
- Participants
- 49 patients
- Exposure
- Post-injection vs pre-injection
- Outcome
- Changes after aspiration and GC injection
- Follow-up
- 3-4 weeks
Methodological detailsbefore-and-after, linear and polynomial mixed-effects regression
- Before-and-after
- Linear and polynomial mixed-effects regression
Main finding
As reported in the abstract
3-4 weeks
Each group vs pre-injectionDifference (effusion depth), mm (95% CI)
Post-injection
−1.05(−1.07 to −0.39)
Each group vs pre-injectionEstimate (95% CI)
Post-injection
difference (peak external knee flexion moment, KFM) 3.33 Nm(0.45–6.22)
Post-injection
difference (peak external knee extension moment, KEM) −2.99 Nm(−5.93 to −0.05)
Post-injection
difference (knee extension strength) 4.70 Nm(0.39–9.00)
Post-injection
difference (knee flexion strength) 3.91 Nm(1.50–6.81)
- Post-injection
- unstandardized β (synovitis score) −0.55 /9 (95% CI −0.97 to −0.12)
- Post-injection
- unstandardized β (Knee Osteoarthritis Outcome Score (KOOS) pain) 5.91 /100 (95% CI 1.86–9.97)
Observational data: associations, not effects.
Further findings
Associations among changes, controlled for time
- Greater synovitis associated with lower knee extension strength
- Lower pain associated with increased knee extension and flexion strength
Original publication
Changes and Associations Between Gait Biomechanics and Knee Inflammation After Aspiration and Glucocorticoid Injection for Knee Osteoarthritis. Arthritis Care Res (Hoboken). Published 6 February 2023. doi:10.
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