Association between thyroid function and osteoarthritis: A population-based cohort study
Main finding · Prevalent knee OA per pmol/L FT4Result — go to the resultOdds ratio 1.04 95% CI 1.01–1.06Authors' conclusion
Our study indicated that higher FT4 concentrations may increase the risk of knee OA.
Study context
- Population
- Participants from the Rotterdam Study with baseline thyroid-stimulating hormone (TSH), free thyroxine (FT4) and joint radiographs (mean age 65 years, 56.3% women)
- Participants
- 9,054 participants
- Exposure
- Higher vs lower TSH and FT4 concentrations
- Outcome
- Prevalence, severity, incidence and progression of hand, hip or knee OA
Methodological detailsmultivariable regression, stratified by sex, age, body mass index (BMI) and weight-bearing physical activity
- Multivariable regression
- Stratified by sex, age, BMI and weight-bearing physical activity
Main finding
Prevalent knee OA per pmol/L FT4
Odds ratio
1.04
95% CI 1.01–1.06
FT4 (per pmol/L)
OR 1.04 (95% CI 1.01–1.06)
Per pmol/L, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | |
|---|---|---|
| Overall progression of knee OA per pmol/L FT4 | 1.03 (1.00–1.07) | |
| Prevalent knee OA per pmol/L FT4, BMI ≥30 kg/m² (subgroup) | 1.05 (1.01–1.08) | |
| Prevalent knee OA per pmol/L FT4, high weight-bearing physical activity (subgroup) | 1.05 (1.01–1.10) | |
| 0.512Odds ratio (log scale) |
Original publication
Association between thyroid function and osteoarthritis: A population-based cohort study. Osteoarthritis Cartilage. Published 12 November 2024. doi:10.
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