Disparities Between Rural and Urban Communities: Response to 18 Months of Diet and Exercise Versus Control for Knee Osteoarthritis and Overweight or Obesity
Authors' conclusion
Among participants with knee osteoarthritis and overweight or obesity, D + E compared to C led to similar pain outcomes in rural and urban dwellers that favored D + E.
Study context
- Population
- Older adults (mean age 64.6 years; 77% women) with knee OA and overweight or obesity, North Carolina
- Participants
- 823 adults
- Comparison
- D + E vs attention control, in rural vs urban dwellers
- Ruraln = 410
- Urbann = 413reference
- Primary endpoint
- Group (rural or urban) by treatment (D + E or C) interaction for WOMAC pain and function
- Follow-up
- 18 months
Methodological detailssubgroup analysis (rural vs urban), general linear models adjusted for covariates
- Subgroup analysis (rural vs urban)
- General linear models adjusted for covariates
Primary result
As reported in the abstract
WOMAC pain, D + E − C by residence
D + E vs CEstimate (95% CI)
Rural
difference (rural) −0.63(−1.31 to 0.06)
Urban
difference (urban) −0.29(−0.99 to 0.41)
Further findings
| Outcome | Estimate | |
|---|---|---|
| WOMAC function, D + E − C by residence · 18 monthsD + Evs CRural · adjusted for baseline differences | difference (rural) −4.60 (95% CI −6.89 to −2.31) | |
| WOMAC function, D + E − C by residence · 18 monthsD + Evs CUrban · adjusted for baseline differences | difference (urban) −1.38 (95% CI −3.73 to 0.94) | |
| −10−505Difference (linear scale) |
| Outcome | P value |
|---|---|
| WOMAC function, D + E − C by residence · 18 monthsRural vs Urban · adjusted for baseline differences | P = 0.054 |
Baseline differences, rural vs urban
- Rural group differed significantly in clinical outcomes, education, comorbidities, medication use and income
- P < 0.05
Original publication
Disparities Between Rural and Urban Communities: Response to 18 Months of Diet and Exercise Versus Control for Knee Osteoarthritis and Overweight or Obesity. Arthritis Care Res (Hoboken). Published 11 November 2024. doi:10.
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