Longitudinal stability of molecular endotypes of knee osteoarthritis patients
Authors' conclusion
Our study showed for the first time that more than half of KOA participants exhibited a longitudinally stable endotype
Study context
- Population
- Knee OA participants from the APPROACH cohort; independent knee OA population from the placebo arm of the oral salmon calcitonin trials226 with complete data
- Participants
- 295 participants
- Exposure
- Structural damage vs Inflammation vs Low tissue turnover
- Outcome
- Longitudinal endotype stability (same independent endotype assignment longitudinally)
- Follow-up
- 6, 12 and 24 months
Methodological detailslongitudinal, K-means clustering, external validation in placebo arm of oral salmon calcitonin trials, 19 biomarkers measured longitudinally
- Longitudinal
- K-means clustering
- External validation in placebo arm of oral salmon calcitonin trials
- 19 biomarkers measured longitudinally
Main finding
As reported in the abstract
Longitudinal endotype stability
| Group | Value | Fleiss' Kappa |
|---|---|---|
| Structural damage | average 59% (range 54–59%) | 0.52 (95% CI: 0.45, 0.60) |
| Inflammation | average 54% (range 52–56%) | 0.61 (95% CI: 0.53, 0.68) |
| Low tissue turnover | average 50% (range 49–52%) | 0.46 (95% CI: 0.39, 0.54) |
Value
Structural damageaverage 59% (range 54–59%)
Inflammationaverage 54% (range 52–56%)
Low tissue turnoveraverage 50% (range 49–52%)
Fleiss' Kappa
Structural damage0.52 (95% CI: 0.45, 0.60)
Inflammation0.61 (95% CI: 0.53, 0.68)
Low tissue turnover0.46 (95% CI: 0.39, 0.54)
- Average overall longitudinal endotype stability
- 55%
- Overall Fleiss' Kappa
- 0.53 (95% CI: 0.46, 0.60)
Observational data: associations, not effects.
Original publication
Longitudinal stability of molecular endotypes of knee osteoarthritis patients. Osteoarthritis Cartilage. Published 8 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →